The purpose of writing this review on gas powered systems (GPS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of Gas Powered System (GPS) including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Therefore the gas powered system have been developed, which prolong the gastric empting time. The improved controlled drug delivery system of the present invention is designed to deliver effectively a drug to a patient over a specific time period (temporal control) and from particular portion of the patients gastrointestinal tract (spatial control).the improved controlled drug delivery system avoids dose dumping and results in the most therapeutic administration of a particular drug to a particular person with a particular ailment to improved the bioavaibility. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
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